Bioactive Small Molecules
Medchemexpress LLC Lomitapide | 182431-12-5 | MFCD16620494 | 99.6% | 693.72 | C39H37F6N3O2 | 5 MG
Lomitapide is a research-grade inhibitor of microsomal triglyceride-transfer protein (MTP) provided as a high-purity solid for laboratory and analytical applications. It exhibits potent in vitro activity against MTP and is used in biochemical and cellular studies for mechanism-of-action and screening work.
- High purity solid suitable for analytical and biochemical assays.
- Potent MTP inhibition with IC50 ≈ 8 nM for sensitive activity profiling.
- Supplied in milligram-scale quantities for screening and validation workflows.
- Well characterized with molecular formula and molecular weight for compound identification.
- Intended for research use only; not for human or clinical applications.
Medchemexpress LLC Endothelial lipase inhibitor-1 | 1466427-02-0 | 98.0% | 406.43 g/mol | C22H22N4O4 | 5 MG
Endothelial lipase inhibitor-1 is a small-molecule research compound that potently inhibits endothelial lipase (IC50 49 nM). It is supplied for laboratory research use only and is provided in solid and DMSO solution formats, with analytical support documents available for quality verification.
- Potent endothelial lipase inhibition (IC50 49 nM).
- High purity (98.02%) suitable for research use.
- Available as solid and ready-to-use DMSO solution formats.
- Soluble in DMSO (25 mg/mL) and formulatable for in vivo dosing.
- Includes supporting documents: data sheet, COA, SDS, HNMR, LCMS.
- Recommended storage: powder -20 °C for long term; in solvent -80 °C.
Apexbio Technology LLC Nigericin sodium salt, 5mg CAS# 28643-80-3
Nigericin sodium salt is an ionophore that exchanges K+ for H+ across biological membranes.Ionophore is a lipid-soluble molecule that transports ions across the cell membrane.In medium with Na+, nigericin scarcely affected ADP-induced platelets aggregation, and slightly inhibited thrombin-induced platelets aggregation. Also, nigericin decreased the cytoplasmic pH in the medium with Na+. The effects of nigericin on platelet aggregation are mainly due to its effects on the cytoplasmic pH [1]. The K+ ionophore nigericin is highly effective as an ionophore for Pb2+. Physiological concentrations of Ca2+ or Mg2+ didnt inhibit nigericin-catalyzed Pb2+ transport, while K+ and Na+ concentrations (0-100 mM) modestly affected Pb2+ transport. Nigericin may be helpful in the treatment of Pb intoxication. Other sizes are also available. Please inqury us for quote.
Apexbio Technology LLC Pazopanib (GW-786034), 500mg. Cas: 444731-52-6 MFCD: MFCD11616589. VEGFR/PDGFR/FGFR inhibitor
Pazopanib is a potent and selective second generation multi-targeted receptor tyrosine kinase inhibitor of vascular endothelial growth factor receptor (VEGFR), platelet-derived growth factor receptor (PDGFR) and c-kit tyrosine kinases. Other sizes are available. Please inqury us for quote.
Cayman Chemical ANTIBODY Carbadox 25g
An inhibitor of FAF1 inhibits chemical hypoxia-induced apoptosis in H9c2 cardiomyocytes and hydrogen peroxide-induced cell death in SH-SY5Y cells at 10 and 20 M respectively reduces decreases in striatal dopamine transporter activity in a mouse model of MPTP-induced Parkinsons disease at 20 mg/kg per day